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From WikiChip
local layout effects
Local layout effects (LLEs) or Layout-dependent effects (LDEs) are envrionmental effects that negatively impact the electrical characteristics of a semiconductor device due to its physical layout and proximity to other features on an integrated circuit.
Overview
The physical environment (i.e., layout) in which a semiconductor device resides in can vary its characteristics. For example, a transistor that is placed close to the edge of a well will exhibit threshold voltage shift due to ion scattering back out of photoresist during ion implantation. All the various device effects are collectivity called Local layout effects (LLEs).
Effects
This list is incomplete; you can help by expanding it.