The 16-bit computer architecture is a microprocessor architecture that has a datapath width or a highest operand width of 16 bits or 2 octets. These architectures typically have a matching register file with registers width of 16 bits.

16-bit microprocessors

• Fairchild MicroFlame 9440
• Ferranti F100-L
• HP MC2
• Intel 8086
• Intel 8088
• Intel 80186
• Intel 80188
• Intel 80286
• Intel MCS-96
• National PACE
• National INS8900
• NEC V50
• TI TMS9900
• TI TMS9980
• TI TMS9995
• TI TMS99105
• TI TMS99110
• USSR 1801
• WDC 65816
• Zilog Z8000

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