| dev model      = Proprietary

| design        = Von Neumann

| format        = Register-Memory

| endianness    = Bi-endian

In 1972, Intel introduced their first set of mnemonics for their instructions. This original set consists of three characters which meant it could easily be encoded into a lookup table. A few years later, when they released their {{intel|8080}} and its instruction set, they also revamped the 8008 mnemonics to match the 8080's ones more closely. The newer mnemonics resemble a primitive version of modern x86 mnemonics. Since 8008 programs can be found using bother mnemonics, both the "old" and the "new" mnemonics are listed below. Both mnemonics results in identical binary values.

| Mnemonic (new)

| Len

{{inst|mn=LMR_s  |col 1=MOV M, R_s  |col 2=1 |op={{bin|11 111 SSS}} |act=Mem = R_s}}

{{inst|mn=ADR_s |col 1=ADD R_s |col 2=1 |op={{bin|10 000 SSS}}  |act=A = A + R_s}}

{{inst|mn=ADM            |col 1=ADD M            |col 2=1 |op={{bin|10 000 111}}  |act=A = A + Mem}}

{{inst|mn=ADI            |col 1=ADI              |col 2=2 |op={{bin|00 000 100}}  |act=A = A + Immed Value}}

{{inst|mn=ACR_s |col 1=ADC R_s |col 2=1 |op={{bin|10 001 SSS}}  |act=A = Carry + R_s}}

{{inst|mn=ACM            |col 1=ADC M            |col 2=1 |op={{bin|10 001 111}}  |act=A = Carry + Mem}}

{{inst|mn=SBR_s  |col 1=SBB R_s |col 2=1 |op={{bin|10 011 SSS}}  |act=A = A - (Carry + R_s)}}

{{inst|mn=SBI            |col 1=SCI               |col 2=2 |op={{bin|00 011 100}}  |act=A = A - (Carry + Immed Value)}}

{{inst|mn=JTC |col 1=JC  |col 2=3 |op={{bin|01 100 000}} |act=If carry = 1, jump to immed address}}

{{inst|mn=JTZ |col 1=JZ  |col 2=3 |op={{bin|01 101 000}} |act=If result = 0, jump to immed address}}

{{inst|mn=JTS |col 1=JM  |col 2=3 |op={{bin|01 110 000}} |act=If sign = 1 (negative), jump to immed address}}

{{inst|mn=JTP |col 1=JPE  |col 2=3 |op={{bin|01 111 000}} |act=If parity = 1 (even), jump to immed address}}

{{inst|mn=CTC |col 1=CC  |col 2=3 |op={{bin|01 100 010}} |act=If carry = 1, save current address and jump to immed address}}

{{inst|mn=CTZ |col 1=CZ  |col 2=3 |op={{bin|01 101 010}} |act=If result = 0, save current address and jump to immed address}}

{{inst|mn=CTS |col 1=CM  |col 2=3 |op={{bin|01 110 010}} |act=If sign = 1 (negative), save current address and jump to immed address}}

{{inst|mn=CTP |col 1=CPE  |col 2=3 |op={{bin|01 111 010}} |act=If parity = 1 (even), save current address and jump to immed address}}

{{inst|mn=RTC |col 1=RC  |col 2=1 |op={{bin|00 100 011}} |act=If carry = 1, return, down one stack level}}

{{inst|mn=RTZ |col 1=RZ  |col 2=1 |op={{bin|00 101 011}}  |act=If result = 0, return, down one stack level}}

{{inst|mn=RTS |col 1=RM  |col 2=1 |op={{bin|00 110 011}} |act=If sign = 1 (negative), return, down one stack level}}

{{inst|mn=RTP |col 1=RPE  |col 2=1 |op={{bin|00 111 011}} |act=If parity = 1 (even), return, down one stack level}}